Intensive management of obesity in people with Prader-Willi syndrome

BJ Nolan; J Proietto; P Sumithran

Journal article

Intensive management of obesity in people with Prader-Willi syndrome

BJ Nolan, J Proietto, P Sumithran

Endocrine | SPRINGER | Published : 2022

DOI: 10.1007/s12020-022-03064-1

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Abstract

Purpose: Prader-Willi syndrome (PWS) is characterised by childhood-onset hyperphagia and obesity however limited data are available to guide treatment of obesity in this population. We aimed to evaluate the safety, tolerability, and efficacy of intensive medical weight loss interventions (very-low-energy diets [VLED] and/or pharmacotherapy) in individuals with PWS attending a specialist obesity management service. Methods: A retrospective audit was undertaken of individuals with PWS attending the Austin Health Weight Control Clinic between January 2010-April 2021. Main outcome measures were weight outcomes, duration of use, and adverse effects. Results: Data were available for 18 patients, o..

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University of Melbourne Researchers

Joseph Proietto Author

Priya Sumithran Author

Brendan Nolan Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. B.J. N. is supported by a NHMRC Postgraduate Scholarship (2003939). P.S. is supported by a NHMRC Investigator Grant (1178482). Open Access funding enabled and organized by CAUL and its Member Institutions.